According to this blog (https://kaitchup.substack.com/p/lessons-from-gguf-evaluation...) the UD_IQ2_M quants are quite strong (rel. error to the base is very low), so it's around 120GB of RAM needed, while the experts can be loaded into VRAM and the rest offloaded into system RAM. It's a high end consumer PC, sure, but not unaffordable. For example, I got an older rig with a RTX 6000 ADA (48GB VRAM), 128 GB RAM and a Threadripper, which runs this quant offloaded at 20 tps