One datapoint: I used to get sore wrists if I didn't take breaks, changed to a Dvorak variant, haven't had sore wrists since then. Used notebook keyboard for years, now have a MS Natural, both fine. Used similar before Dvorak, had issues. Have Herman Miller Embody, which I adore, but it hasn't magically improved my posture - still some work to do.
how's the desk position? i found this was actually the most important thing...crucial to get those elbows so that the angle from bicep to forearm is about 105 degrees.
