Anyone know if there's a connection with Mary Shelley? His early childhood, motivation, and preparation for travels (from the article and Wikipedia) reads similarly enough to that of the protagonist of the framing story in Frankenstein that, were his history widely known at the time, it must surely have been an inspiration for it. Either that or there was something in the air and that kind of story was (relatively) common.
"Humboldt's world view of one vast interconnected system, through which he drew three-dimensional lines tracing, for instance, rock formations, atmospheric and oceanic currents and ecological communities is probably the most impressive feature of his Personal narrative. The book is a rich store of facts, history and observations which Darwin and many other writers have been plundering for almost two centuries. While still a great travel story, it is perhaps too prolix for modern readers and the ratio of science to (somewhat tedious) history certainly shrinks in the later volumes. Nevertheless, few books can provide such an insight into a world divided between 'Old' or 'New' in a way very hard to appreciate today. When Mary Shelley wrote Frankenstein in 1818 she had his 'creation' declare that he and his bride 'will go to the vast wilds of South America', a place as far from 'civilisation' as possible where they can do no harm. Those vast wilds were probably known to her from the Personal narrative."