Depends on the country, but I've heard of several areas (in Africa and Asia) where they're looking for pilots to serve remote areas. They have trouble finding them because it's one of the most dangerous jobs you can do (landing on a runway isn't fun when animals start crossing it) and many people quit after realizing that.
Here the usual risks apply, but it is mostly short flights between small villages next to amazon rivers. A 15 minutes flight is equivalent to a 3 hours boat ride on the river.. Imagine the increase in coverage a vaccination nurse can do with a small ultralight seaplane. http://www.aircam.com/
